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1

Anatomical, Physiological and Metabolic Changes with Gestational Age during Normal Pregnancy

Dr Khaled Abduljalil, Penny Furness, Trevor N. Johnson, Amin Rostami-Hodjegan, Hora Soltani

Journal:

Clinical Pharmacokinetics

Année:

2012

Langue:

english

Fichier:

PDF, 365 KB

english, 2012

2

Prediction of Intestinal First-Pass Drug Metabolism

Yang, Jiansong, Jamei, Masoud, Yeo, Karen, Tucker, Geoffrey, Rostami-Hodjegan, Amin

Journal:

Current Drug Metabolism

Année:

2007

Langue:

english

Fichier:

PDF, 257 KB

english, 2007

3

Weight-related dosing, timing and monitoring hydrocortisone replacement therapy in patients with adrenal insufficiency

Peak M. Mah, Richard C. Jenkins, Amin Rostami-Hodjegan, John Newell-Price, Anita Doane, Victoria Ibbotson, Geoffrey T. Tucker, Richard J. Ross

Journal:

Clinical Endocrinology

Année:

2004

Langue:

english

Fichier:

PDF, 243 KB

english, 2004

4

Simulation and prediction of in vivo drug metabolism in human populations from in vitro data

Rostami-Hodjegan, Amin, Tucker, Geoffrey T.

Journal:

Nature Reviews Drug Discovery

Année:

2007

Langue:

english

Fichier:

PDF, 798 KB

english, 2007

5

Absolute abundance and function of intestinal drug transporters: a prerequisite for fully mechanistic in vitro-in vivo extrapolation of oral drug absorption

Harwood, M. D., Neuhoff, S., Carlson, G. L., Warhurst, G., Rostami-Hodjegan, A.

Journal:

Biopharmaceutics & Drug Disposition

Année:

2013

Langue:

english

Fichier:

PDF, 984 KB

english, 2013

6

Prediction of in vivo drug clearance from in vitro data. I: Impact of inter-individual variability

Howgate, E. M., Rowland Yeo, K., Proctor, N. J., Tucker, G. T., Rostami-Hodjegan, A.

Journal:

Année:

2006

Langue:

english

Fichier:

PDF, 735 KB

english, 2006

7

Interplay of Metabolism and Transport in Determining Oral Drug Absorption and Gut Wall Metabolism: A Simulation Assessment Using the “Advanced Dissolution, Absorption, Metabolism (ADAM)” Model

S. Darwich, A., Neuhoff, S., Jamei, M., Rostami-Hodjegan, A.

Journal:

Current Drug Metabolism

Année:

2010

Langue:

english

Fichier:

PDF, 1.95 MB

english, 2010

8

IMI – Oral biopharmaceutics tools project – Evaluation of bottom-up PBPK prediction success part 3: Identifying gaps in system parameters by analysing In Silico performance across different compound classes

Darwich, Adam S., Margolskee, Alison, Pepin, Xavier, Aarons, Leon, Galetin, Aleksandra, Rostami-Hodjegan, Amin, Carlert, Sara, Hammarberg, Maria, Hilgendorf, Constanze, Johansson, Pernilla, Karlsson,

Journal:

European Journal of Pharmaceutical Sciences

Année:

2016

Langue:

english

Fichier:

PDF, 1.38 MB

english, 2016

9

IMI – oral biopharmaceutics tools project – evaluation of bottom-up PBPK prediction success part 1: Characterisation of the OrBiTo database of compounds

Margolskee, Alison, Darwich, Adam S., Pepin, Xavier, Pathak, Shriram M., Bolger, Michael B., Aarons, Leon, Rostami-Hodjegan, Amin, Angstenberger, Jonas, Graf, Franziska, Laplanche, Loic, Müller, Thoma

Journal:

European Journal of Pharmaceutical Sciences

Année:

2016

Langue:

english

Fichier:

PDF, 1.49 MB

english, 2016

10

IMI – Oral Biopharmaceutics Tools project – Evaluation of Bottom-up PBPK Prediction Success Part 2: An Introduction to the Simulation Exercise and Overview of Results

Margolskee, Alison, Darwich, Adam S., Pepin, Xavier, Aarons, Leon, Galetin, Aleksandra, Rostami-Hodjegan, Amin, Carlert, Sara, Hammarberg, Maria, Hilgendorf, Constanze, Johansson, Pernilla, Karlsson,

Journal:

European Journal of Pharmaceutical Sciences

Année:

2016

Langue:

english

Fichier:

PDF, 1.55 MB

english, 2016

11

Physiologically based pharmacokinetic modelling to guide drug delivery in older people

Chetty, Manoranjenni, Johnson, Trevor N., Polak, Sebastian, Salem, Farzaneh, Doki, Kosuke, Rostami-Hodjegan, Amin

Journal:

Advanced Drug Delivery Reviews

Année:

2018

Langue:

english

Fichier:

PDF, 5.94 MB

english, 2018

12

Are there differences in the catalytic activity per unit enzyme of recombinantly expressed and human liver microsomal cytochrome P450 2C9? A systematic investigation into inter-system extrapolation factors

H. K. Crewe, Z. E. Barter, K. Rowland Yeo, A. Rostami-Hodjegan

Journal:

Biopharmaceutics & Drug Disposition

Année:

2011

Langue:

english

Fichier:

PDF, 716 KB

english, 2011

13

Fraction absorbed (Fabs): Different connotations and confusion for the literature?

K. Sandy Pang, Amin Rostami-Hodjegan

Journal:

Biopharmaceutics & Drug Disposition

Année:

2011

Langue:

english

Fichier:

PDF, 54 KB

english, 2011

14

Physiologically based modelling of inhibition of metabolism and assessment of the relative potency of drug and metabolite: dextromethorphan vs. dextrorphan using quinidine inhibition

A. A. Moghadamnia, A. Rostami-Hodjegan, R. Abdul-Manap, C. E. Wright, A. H. Morice, G. T. Tucker

Journal:

British Journal of Clinical Pharmacology

Année:

2003

Langue:

english

Fichier:

PDF, 977 KB

english, 2003

15

Biosimulation in Biomedical Research, Health Care and Drug Development Volume 75 || The Approach to Model Building

Mosekilde, Erik, Sosnovtseva, Olga, Rostami-Hodjegan, Amin

Année:

2012

Langue:

english

Fichier:

PDF, 687 KB

english, 2012

16

Application of a Systems Approach to the Bottom-Up Assessment of Pharmacokinetics in Obese Patients

Dr Cyrus Ghobadi, Trevor N. Johnson, Mohsen Aarabi, Lisa M. Almond, Aurel Constant Allabi, Karen Rowland-Yeo, Masoud Jamei, Amin Rostami-Hodjegan

Journal:

Clinical Pharmacokinetics

Année:

2011

Langue:

english

Fichier:

PDF, 441 KB

english, 2011

17

Predicting drug–drug interactions: application of physiologically based pharmacokinetic models under a systems biology approach

Yeo, Karen Rowland, Jamei, Masoud, Rostami-Hodjegan, Amin

Journal:

Expert Review of Clinical Pharmacology

Année:

2013

Langue:

english

Fichier:

PDF, 2.83 MB

english, 2013

18

Do Children Have the Same Vulnerability to Metabolic Drug-Drug Interactions as Adults? A Critical Analysis of the Literature

Salem, Farzaneh, Rostami-Hodjegan, Amin, Johnson, Trevor N.

Journal:

Journal of Clinical Pharmacology

Année:

2013

Langue:

english

Fichier:

PDF, 437 KB

english, 2013

19

A New Rapidly Absorbed Paracetamol Tablet Containing Sodium Bicarbonate. I. A Four-Way Crossover Study to Compare the Concentration–Time Profile of Paracetamol from the New Paracetamol/Sodium Bicarbonate Tablet and a Conventional Paracetamol Tablet in Fed and Fasted Volunteers

Rostami-Hodjegan, A., Shiran, M. R., Ayesh, R., Grattan, T. J., Burnett, I., Darby-Dowman, A., Tucker, G. T.

Journal:

Drug Development and Industrial Pharmacy

Année:

2002

Langue:

english

Fichier:

PDF, 336 KB

english, 2002

20

A Physiologically Based Pharmacokinetic Modeling Approach to Predict Disease–Drug Interactions: Suppression of CYP3A by IL-6

Machavaram, K K, Almond, L M, Rostami-Hodjegan, A, Gardner, I, Jamei, M, Tay, S, Wong, S, Joshi, A, Kenny, J R

Journal:

Clinical Pharmacology & Therapeutics

Année:

2013

Langue:

english

Fichier:

PDF, 1.26 MB

english, 2013

21

Modeling and predicting drug pharmacokinetics in patients with renal impairment

Rowland Yeo, Karen, Aarabi, Mohsen, Jamei, Masoud, Rostami-Hodjegan, Amin

Journal:

Expert Review of Clinical Pharmacology

Année:

2011

Langue:

english

Fichier:

PDF, 539 KB

english, 2011

22

Pharmacometrics in Pregnancy: An Unmet Need

Ke, Alice Ban, Rostami-Hodjegan, Amin, Zhao, Ping, Unadkat, Jashvant D.

Journal:

Annual Review of Pharmacology

Année:

2014

Langue:

english

Fichier:

PDF, 318 KB

english, 2014

23

Implications of mechanism-based inhibition of CYP2D6 for the pharmacokinetics and toxicity of MDMA

Yang, J., Jamei, M., Heydari, A., Yeo, K. R., de la Torre, R., Farre, M., Tucker, G. T., Rostami-Hodjegan, A.

Journal:

Journal of Psychopharmacology

Année:

2006

Langue:

english

Fichier:

PDF, 155 KB

english, 2006

24

The Simcyp ® Population-based ADME Simulator

Jamei, Masoud, Marciniak, Steve, Feng, Kairui, Barnett, Adrian, Tucker, Geoffrey, Rostami-Hodjegan, Amin

Journal:

Expert Opinion on Drug Metabolism & Toxicology

Année:

2009

Langue:

english

Fichier:

PDF, 1.77 MB

english, 2009

25

Prediction of in vivo drug clearance from in vitro data. II: Potential inter-ethnic differences

Inoue, S., Howgate, E. M., Rowland-Yeo, K., Shimada, T., Yamazaki, H., Tucker, G. T., Rostami-Hodjegan, A.

Journal:

Année:

2006

Langue:

english

Fichier:

PDF, 196 KB

english, 2006

26

Combining the ‘bottom up’ and ‘top down’ approaches in pharmacokinetic modelling: fitting PBPK models to observed clinical data

Tsamandouras, Nikolaos, Rostami-Hodjegan, Amin, Aarons, Leon

Journal:

British Journal of Clinical Pharmacology

Année:

2015

Langue:

english

Fichier:

PDF, 954 KB

english, 2015

27

Applications of linking PBPK and PD models to predict the impact of genotypic variability, formulation differences, differences in target binding capacity and target site drug concentrations on drug responses and variability

Chetty, Manoranjenni, Rose, Rachel H., Abduljalil, Khaled, Patel, Nikunjkumar, Lu, Gaohua, Cain, Theresa, Jamei, Masoud, Rostami-Hodjegan, Amin

Journal:

Frontiers in Pharmacology

Année:

2014

Langue:

english

Fichier:

PDF, 2.80 MB

english, 2014

28

Scaling Factors for the Extrapolation of In Vivo Metabolic Drug Clearance From In Vitro Data: Reaching a Consensus on Values of Human Micro-somal Protein and Hepatocellularity Per Gram of Liver

Barter, Zoe, Bayliss, Martin, Beaune, Philip, Boobis, Alan, Carlile, David, Edwards, Robert, Brian Houston, J., Lake, Brian, Lipscomb, John, Pelkonen, Olavi, Tucke, Geoffrey, Rostami-Hodjegan, Amin

Journal:

Current Drug Metabolism

Année:

2007

Langue:

english

Fichier:

PDF, 850 KB

english, 2007

29

Deconvolution and IVIVC: Exploring the Role of Rate-Limiting Conditions

Margolskee, Alison, Darwich, Adam S., Galetin, Aleksandra, Rostami-Hodjegan, Amin, Aarons, Leon

Journal:

The AAPS Journal

Année:

2016

Langue:

english

Fichier:

PDF, 2.49 MB

english, 2016

30

A Framework for Assessing Inter-individual Variability in Pharmacokinetics Using Virtual Human Populations and Integrating General Knowledge of Physical Chemistry, Biology, Anatomy, Physiology and Genetics: A Tale of ‘Bottom-Up’ vs ‘Top-Down’ Recognition of Covariates

Jamei, Masoud, Dickinson, Gemma L., Rostami-Hodjegan, Amin

Journal:

Drug Metabolism and Pharmacokinetics

Année:

2009

Langue:

english

Fichier:

PDF, 1.12 MB

english, 2009

31

Metformin and cimetidine: Physiologically based pharmacokinetic modelling to investigate transporter mediated drug–drug interactions

Burt, H.J., Neuhoff, S., Almond, L., Gaohua, L., Harwood, M., Jamei, M., Rostami-Hodjegan, A., Tucker, G.T., Rowland-Yeo, K.

Journal:

European Journal of Pharmaceutical Sciences

Année:

2016

Langue:

english

Fichier:

PDF, 2.33 MB

english, 2016

32

Prediction of drug-drug interactions arising from CYP3A induction using a physiologically-based dynamic model

Almond, L. M., Mukadam, S., Gardner, I., Okialda, K., Wong, S., Hatley, O., Tay, S., Rowland-Yeo, K., Jamei, M., Rostami-Hodjegan, A., Kenny, J. R.

Journal:

Drug Metabolism and Disposition

Année:

2016

Langue:

english

Fichier:

PDF, 9.28 MB

english, 2016

33

Novel minimal physiologically-based model for the prediction of passive tubular reabsorption and renal excretion clearance

Scotcher, Daniel, Jones, Christopher, Rostami-Hodjegan, Amin, Galetin, Aleksandra

Journal:

European Journal of Pharmaceutical Sciences

Année:

2016

Langue:

english

Fichier:

PDF, 982 KB

english, 2016

34

Generic Vs Proprietary Clozapine: Initial UK Experience

Spencer, Edgar P, Morgan, Phillip E, Flanagan, Robert J, Rostami-Hodjegan, Amin

Journal:

Therapeutic Drug Monitoring

Année:

2005

Langue:

english

Fichier:

PDF, 691 KB

english, 2005

35

Development of a permeability-limited model of the human brain and cerebrospinal fluid (CSF) to integrate known physiological and biological knowledge: Estimating time varying CSF drug concentrations and their variability using in vitro data

Gaohua, Lu, Neuhoff, Sibylle, Johnson, Trevor N., Rostami-Hodjegan, Amin, Jamei, Masoud

Journal:

Drug Metabolism and Pharmacokinetics

Année:

2016

Langue:

english

Fichier:

PDF, 1.39 MB

english, 2016

36

Methodologies for Investigating Drug Metabolism at the Early Drug Discovery Stage: Prediction of Hepatic Drug Clearance and P450 Contribution

Emoto, Chie, Murayama, Norie, Rostami-Hodjegan, Amin, Yamazaki, Hiroshi

Journal:

Current Drug Metabolism

Année:

2010

Langue:

english

Fichier:

PDF, 232 KB

english, 2010

37

Towards a Quantitative Framework for the Prediction of DDIs Arising from Cytochrome P450 Induction

Almond, L., Yang, J., Jamei, M., Tucker, G., Rostami-Hodjegan, A.

Journal:

Current Drug Metabolism

Année:

2009

Langue:

english

Fichier:

PDF, 349 KB

english, 2009

38

The absorption kinetics of ketoconazole plays a major role in explaining the reported variability in the level of interaction with midazolam: Interplay between formulation and inhibition of gut wall and liver metabolism

Liu, Bo, Crewe, H. Kim, Ozdemir, Mahmut, Rowland Yeo, Karen, Tucker, Geoffrey, Rostami-Hodjegan, Amin

Journal:

Biopharmaceutics & Drug Disposition

Année:

2017

Langue:

english

Fichier:

PDF, 1.42 MB

english, 2017

39

Principles in incorporating IVIVE into PBPK

Rostami-Hodjegan, Amin

Journal:

Drug Metabolism and Pharmacokinetics

Année:

2017

Langue:

english

Fichier:

PDF, 113 KB

english, 2017

40

Drugs Being Eliminated via the Same Pathway Will Not Always Require Similar Pediatric Dose Adjustments

Calvier, Elisa A. M., Krekels, Elke H. J., Yu, Huixin, Välitalo, Pyry A. J., Johnson, Trevor N., Rostami-Hodjegan, Amin, Tibboel, Dick, van der Graaf, Piet H., Danhof, Meindert, Knibbe, Catherijne A.

Journal:

CPT: Pharmacometrics & Systems Pharmacology

Année:

2018

Langue:

english

Fichier:

PDF, 854 KB

english, 2018

41

Data Generated by Quantitative LC-MS Proteomics Are Only the Start and Not the Endpoint: Optimization of QconCAT-Based Measurement of Hepatic UDP-Glucuronosyltransferase Enzymes with Reference to Catalytic Activity

Achour, Brahim, Dantonio, Alyssa, Niosi, Mark, Novak, Jonathan J, Al-Majdoub, Zubida M, Goosen, Theunis C, Rostami-Hodjegan, Amin, Barber, Jill

Journal:

Drug Metabolism and Disposition

Année:

2018

Langue:

english

Fichier:

PDF, 1.65 MB

english, 2018

42

Mass Spectrometry of Human Transporters

Achour, Brahim, Al-Majdoub, Zubida, Rostami-Hodjegan, Amin, Barber, Jill

Journal:

Annual Review of Analytical Chemistry

Année:

2020

Langue:

english

Fichier:

PDF, 845 KB

english, 2020

43

Considerations and Caveats when Applying Global Sensitivity Analysis Methods to Physiologically Based Pharmacokinetic Models

Liu, Dan, Li, Linzhong, Rostami-Hodjegan, Amin, Bois, Frederic Y., Jamei, Masoud

Journal:

The AAPS Journal

Année:

2020

Fichier:

PDF, 1.52 MB

2020

44

P247 - indoxyl sulfate albumin-facilitated transport via renal drug transporter OAT1 â translation from microfluidic in vitro system to healthy and subjects with severe kidney disease

van der Made, Thom, Fedeconstante, Michele, Scotcher, Daniel, Rostami-Hodjegan, Amin, Masereeuw, Rosalinde, Galetin, Aleksandra

Journal:

Drug Metabolism and Pharmacokinetics

Année:

2020

Fichier:

PDF, 48 KB

2020

45

Physiologically based pharmacokinetic (PBPK) modeling: It is here to stay!

Amin Rostami-Hodjegan, Ikumi Tamai, K. Sandy Pang

Journal:

Biopharmaceutics & Drug Disposition

Année:

2012

Langue:

english

Fichier:

PDF, 63 KB

english, 2012

46

Determination of a quantitative relationship between hepatic CYP3A51/3 and CYP3A4 expression for use in the prediction of metabolic clearance in virtual populations

Z. E. Barter, H. F. Perrett, K. Rowland Yeo, D. Allorge, M. S. Lennard, A. Rostami-Hodjegan

Journal:

Biopharmaceutics & Drug Disposition

Année:

2010

Langue:

english

Fichier:

PDF, 509 KB

english, 2010

47

Bottom-up modeling and simulation of tacrolimus clearance: prospective investigation of blood cell distribution, sex and CYP3A5 expression as covariates and assessment of study power

Hisakazu Ohtani, Zoe Barter, Tsuyoshi Minematsu, Masatoshi Makuuchi, Yasufumi Sawada, Amin Rostami-Hodjegan

Journal:

Biopharmaceutics & Drug Disposition

Année:

2011

Langue:

english

Fichier:

PDF, 241 KB

english, 2011

48

Sequence- and schedule-dependent enhancement of zoledronic acid induced apoptosis by doxorubicin in breast and prostate cancer cells

Helen L. Neville-Webbe, Amin Rostami-Hodjegan, Catherine A. Evans, Robert E. Coleman, Ingunn Holen

Journal:

International Journal of Cancer

Année:

2005

Langue:

english

Fichier:

PDF, 138 KB

english, 2005

49

Prediction of plasma protein binding displacement and its implications for quantitative assessment of metabolic drug–drug interactions from in vitro data

Hege Christensen, Mark Baker, Geoffrey T. Tucker, Amin Rostami-Hodjegan

Journal:

Journal of Pharmaceutical Sciences

Année:

2006

Langue:

english

Fichier:

PDF, 231 KB

english, 2006

50

Metabolism of dextrorphan by CYP2D6 in different recombinantly expressed systems and its implications for the in vitro assessment of dextromethorphan metabolism

Linh M. Van, Sunil Sarda, Judith A. Hargreaves, Amin Rostami-Hodjegan

Journal:

Journal of Pharmaceutical Sciences

Année:

2009

Langue:

english

Fichier:

PDF, 240 KB

english, 2009